Cellular Expression of α7 Nicotinic Acetylcholine Receptor Protein in the Temporal Cortex in Alzheimer's and Parkinson's Disease— A Stereological Approach
Identifieur interne : 001C56 ( Main/Exploration ); précédent : 001C55; suivant : 001C57Cellular Expression of α7 Nicotinic Acetylcholine Receptor Protein in the Temporal Cortex in Alzheimer's and Parkinson's Disease— A Stereological Approach
Auteurs : Carolin Banerjee ; Jens R. Nyengaard [Danemark] ; Andrea Wevers ; Rob A. I. De Vos [Pays-Bas] ; Ernst N. H. Jansen Steur [Pays-Bas] ; Jon Lindstrom ; Kirsten Pilz ; Sonja Nowacki ; Wilhelm Bloch ; Hannsjörg SchröderSource :
- Neurobiology of Disease [ 0969-9961 ] ; 2000.
Abstract
Cognitive deficits in Alzheimer's and Parkinson's disease are closely related to disturbed cholinergic transmission. The decrease of nicotinic acetylcholine receptor protein has been assessed by Western blotting and immunohistochemistry. Stereology, however, has not been used to assess numbers of receptor-expressing human cerebrocortical neurons. Our approach applies a combination of α7 subunit-immunohistochemistry with a stereological technique using defined stretches of pial surface as reference standard. The number of α7 subunit protein-expressing neurons in the Alzheimer temporal cortices amounted to approximately half of that of controls while numbers in Parkinson patients lay in between. No differences in the total number of neurons were seen. These results corroborate nonstereological studies on Alzheimer cortices and for the first time show a similar decrease in receptor expression in Parkinson's disease. They provide evidence that not only Alzheimer dementia but also cognitive deficits in Parkinson's disease may be related to decreased nicotinic receptor expression.
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DOI: 10.1006/nbdi.2000.0317
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The decrease of nicotinic acetylcholine receptor protein has been assessed by Western blotting and immunohistochemistry. Stereology, however, has not been used to assess numbers of receptor-expressing human cerebrocortical neurons. Our approach applies a combination of α7 subunit-immunohistochemistry with a stereological technique using defined stretches of pial surface as reference standard. The number of α7 subunit protein-expressing neurons in the Alzheimer temporal cortices amounted to approximately half of that of controls while numbers in Parkinson patients lay in between. No differences in the total number of neurons were seen. These results corroborate nonstereological studies on Alzheimer cortices and for the first time show a similar decrease in receptor expression in Parkinson's disease. 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